Publications

15. Phintha, A.; Lukowski, A. L.; Chaiyen, P. Unlocking the catalytic precision of ligand-controlled enzymatic halogenation. Proc. Natl. Acad. Sci. 2025, 122, e2409479122. https://doi.org/10.1073/pnas.2409479122

14. Adak, S.; Ye, N.; Calderone, L. A.; Duan, M.; Lubeck, W.; Schäfer, R. J. B.; Lukowski, A. L.; Houk, K. N.; Pandelia, M.-E.; Drennan, C. L.; Moore, B. S. A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile. Nat. Chem. 2024, 16, 1989. https://www.nature.com/articles/s41557-024-01603-z

Prior to 2024:

13.     Lukowski, A. L.†; Hubert, F. M.; Ngo, T.-E.; Avalon, N. E.; Gerwick, W. H.; Moore, B. S. Enzymatic halogenation of terminal alkynes. J. Am. Chem. Soc. 2023, 145, 18716. †Corresponding Author https://doi.org/10.1021/jacs.3c05750

12.     Zetzsche, L. E.*; Yazarians, J. A.*; Chakrabarty, S.; Hinze, M. E.; Murray, L. A. M.; Lukowski, A. L.; Joyce, L. A.; Narayan, A. R. H. Biocatalytic oxidative cross-coupling reactions for biaryl bond formation. Nature 2022, 603, 79. https://doi.org/10.1038/s41586-021-04365-7

11.     Adak, S.*; Lukowski, A. L.*; Schäfer, R. J. B.; Moore, B. S. From tryptophan to toxin: Nature’s convergent biosynthetic strategy to aetokthonoxin. J. Am. Chem. Soc. 2022, 144, 2861. https://doi.org/10.1021/jacs.1c12778

10.     Purdy, T. N.; Moore, B. S.; Lukowski, A. L. Harnessing ortho-quinone methides in natural product biosynthesis and biocatalysis. J. Nat. Prod. 2022, 85, 688. https://doi.org/10.1021/acs.jnatprod.1c01026

9.     Liu, J.; Tian, J.; Perry, C.; Lukowski, A. L.; Doukov, T. I.; Narayan, A. R. H.; Bridwell-Rabb, J. Design principles for site-selective hydroxylation by a Rieske oxygenase. Nat. Commun. 2022, 13, 255. https://doi.org/10.1038/s41467-021-27822-3

8.     Lukowski, A. L.*; Liu, J.*; Bridwell-Rabb, J.; Narayan, A. R. H. Structural basis for divergent C–H hydroxylation selectivity in two Rieske oxygenases. Nat. Commun. 2020, 11, 2991. https://doi.org/10.1038/s41467-020-16729-0

7.     Denomme, N.; Lukowski, A. L.; Hull, J. M.; Jameson, M. B.; Bouza, A.A.; Narayan, A. R. H.; Isom, L. L. The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human NaV1.1 in addition to NaV1.6. Neurosci. Lett. 2020, 724, 134853. https://doi.org/10.1016/j.neulet.2020.134853

6.     Lukowski, A. L.; Mallik, L.; Carlson, B. M.; Hinze, M. E.; Ellinwood, D. C.; Pyser, J. B.; Koutmos, M.; Narayan, A. R. H. Substrate promiscuity of a paralytic shellfish toxin amidinotransferase. ACS Chem. Biol. 2020, 15, 626–631. https://doi.org/10.1021/acschembio.9b00964

5.     Lukowski, A. L.; Denomme, N.; Hinze, M. E.; Hall, S.; Isom, L. L.; Narayan, A. R. H. Biocatalytic detoxification of paralytic shellfish toxins. ACS Chem. Biol. 2019, 14, 941–948. https://doi.org/10.1021/acschembio.9b00123

4.  Rodríguez Benítez, A.; Tweedy, S.; Baker Dockrey, S. A.; Lukowski, A. L.; Wymore, T.; Khare, D.; Brooks, C.; Palfey, B. A.; Smith, J. L.; Narayan, A. R. H. Structural basis for selectivity in flavin-dependent monooxygenase catalyzed oxidative dearomatization. ACS Catal. 2019, 9, 3633–3640. https://doi.org/10.1021/acscatal.8b04575

3.  Lukowski, A. L. and Narayan, A. R. H. Natural voltage-gated sodium channel ligands: Biosynthesis and biology. ChemBioChem. 2019, 20, 1–12. https://doi.org/10.1002/cbic.201800754

2.  Lukowski, A. L.; Ellinwood, D. C.; Hinze, M. E.; DeLuca, R. J.; Du Bois, J.; Hall, S.; Narayan, A. R. H. C–H hydroxylation in paralytic shellfish toxin biosynthesis. J. Am. Chem. Soc. 2018, 140, 11863­–11869. https://doi.org/10.1021/jacs.8b08901

  • Journal of the American Chemical Society Spotlight Article

1.  Baker Dockrey, S. A.; Lukowski, A. L.; Becker, M. R.; Narayan, A. R. H. Biocatalytic site- and enantioselective oxidative dearomatization of phenols. Nat. Chem. 2018, 10, 119–125. https://doi.org/10.1038/nchem.2879